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SNCB Antibody

Rabbit Monoclonal Antibody

  • WB - SNCB Antibody AJ1096a
    A. Western blot analysis on fetal brain lysate using anti-beta synuclein RabMAb (Cat. #AJ1096a), dilution 1:10,000.
  • IHC - SNCB Antibody AJ1096a
    B. Immunohistochemical staining of paraffin-embedded human brain using anti-Beta-Synuclein RabMAb (Cat. #AJ1096a).
  • IF - SNCB Antibody AJ1096a
    C. Immunofluorescent staining of PC12 cells using anti-Beta-Synuclein RabMAb (Cat. #AJ1096a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16143
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1537Y
Calculated MW 14288 Da
Gene ID 6620
Other Names Beta-synuclein, SNCB
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Beta Synuclein was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNCB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Cellular Location Cytoplasm.
Tissue Location Expressed predominantly in brain; concentrated in presynaptic nerve terminals
Research Areas
Citations (0)

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The Beta-Synuclein protein is highly homologous to the alpha-synuclein protein for which two mutations were reported in some familial cases of Parkinson disease. It has been shown that both alpha- and beta-synucleins may be able to inhibit phospholipase D2 selectively (1). Recent studies have shown that the neurodegenerative process in disorders with Lewy body formation, such as Parkinson's disease and dementia with Lewy bodies, is associated with alpha-synuclein accumulation and that beta-synuclein might protect the central nervous system from the neurotoxic effects of alpha-synuclein (2). results raise the possibility that beta-synuclein might be a natural negative regulator of alpha-synuclein aggregation and that a similar class of endogenous factors might regulate the aggregation state of other molecules involved in neurodegeneration. Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders (3).


1. Lavedan C, et al. Genomics 54(1):173-5, 1998
2. Hashimoto M, et al. J Biol Chem 279(22):23622-9, 2004
3. Hashimoto M, et al. Neuron 32(2):213-23, 2001

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Cat# AJ1096a
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