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SRC Antibody

Rabbit Monoclonal Antibody

  • WB - SRC Antibody AJ1112a
    Fig 1. Western blot analysis on SKBR-3 cell lysate using anti-C35 RabMAb (Cat. #AJ1112a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRT3
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2678
Calculated MW 12403 Da
Gene ID 84299
Other Names Migration and invasion enhancer 1, HBV X-transactivated gene 4 protein, HBV XAg-transactivated protein 4, Protein C35, MIEN1, C17orf37, RDX12, XTP4
Target/Specificity A synthetic peptide corresponding to residues in human C35 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSRC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MIEN1
Synonyms C17orf37, RDX12, XTP4
Function Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Cellular Location Cytoplasm, cytosol. Cell membrane; Lipid- anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions
Tissue Location Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
Citations (0)

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C35 (C17orf37, XTP4, ORB3) is a novel cancer marker encoded by a gene located on chromosome 17, adjacent to the Her2 oncogene. Similar to Her2, C35 is overexpressed in cancer tissues, in particular breast and prostate cancer tissues, but not in the normal homolog tissues. The functional role of C35 has not been identified. However, an analysis of predicted functional motifs of the gene product suggests that it may play a role in signal transduction and redox-related process (1). In prostate cancer, the downregulation of C35 leads to suppression of both Akt phospholyation and NF-kappa B activity. This suggests C35 might be involved in increasing the invasive potential of prostate cancer cells by NF-kappaB-mediated downstream target genes (2). Along with its tumor specific expression, C35 expression is persistent throughout tumor progression. Therefore, C35 is considered as an ideal biomarker for the diagnosis of both early-stage and late-stage cancer, and a possible anti-cancer therapeutic target (1, 2).


1. Evans EE et al., Mol Cancer Ther. 5(11):2919-30, 2006. 2. Dasgupta S, et al., Oncogene 28(32):2860-72, 2009.

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Cat# AJ1112a

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