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Caspase-5 Antibody

Rabbit Monoclonal Antibody

  • WB - Caspase-5 Antibody AJ1132a
    A. Western blot analysis on HeLa cell lysate using anti-Caspase 5 RabMAb (Cat. #AJ1132a), dilution 1:10,000
  • IHC - Caspase-5 Antibody AJ1132a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Caspase 5 RabMAb .(Cat. #AJ1132a).
  • IF - Caspase-5 Antibody AJ1132a
    C. Immunofluorescent staining of HeLa cells using anti-Caspase 5 RabMAb.(Cat. #AJ1132a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51878
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP876Y
Calculated MW 49736 Da
Gene ID 838
Other Names Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3
Target/Specificity A synthetic peptide corresponding to N-terminal residues of human Caspase-5 was used as an immunogen. Based on amino acids homology, this antibody will not recognize either p20 or p10 subunits of Caspase-5.
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCaspase-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP5
Synonyms ICH3
Function Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
Tissue Location Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle
Research Areas
Citations (0)

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Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-5 (ICH-3, ICEREL-III, TY protease) is a member of the caspase-1 subfamily and it is an upstream mediator of apoptosis. Caspase-5 is highly expressed in lung, liver, and skeletal muscle, and similar to Caspase-4, its overexpression can induce cellular apoptosis (1). A tetramer, Caspase-5 separates into two subunits of a 20kda (p20) and 10kda (p10) after activation. In vitro, Caspase-5 can be cleaved by GranB, a major player in Cytotoxic T lymphocytes (CTL) induced apoptosis (2). In vivo, the Caspase-5 expression is elevated by LPS and IFNg. Caspase-5 induced apoptosis can be inhibited by CrmA and Bcl-2. Caspase-5 has also been implicated in cellular inflammatory response and in the microsatellite mutator pathway for cancer (3).


1. Kamada S, et al. Cell Death Differ 4:473-478. 1997.
2. Wang S. et al. J. Biol. Chem. 271: 20580-20587, 1996.
3. Schwartz S, et al. Cancer Res 59:2995-3002, 1999.

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Cat# AJ1132a
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