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Caspase-7 Antibody

Rabbit Monoclonal Antibody

  • WB - Caspase-7 Antibody AJ1134a
    A. Western blot analysis of Jurkat cell lysate using anti Caspase 7 RabMab cat# 1032 -1
  • IHC - Caspase-7 Antibody AJ1134a
    B.Immunohistochemical analysis of_paraffin embedded human skin cancer tissue using anti Caspase 7 RabMab catalog# 1032 -1
  • IF - Caspase-7 Antibody AJ1134a
    C. Immunofluorescent staining of HeLa cells using anti Caspase 7 RabMab cat# 1032 -1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55210
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names E22
Calculated MW 34277 Da
Gene ID 840
Other Names Caspase-7, CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11, CASP7, MCH3
Target/Specificity A synthetic peptide corresponding to residues near N-terminus of human Caspase-7 was used as immunogen. The antibody should recognize both pro-form and p20 cleaved-form. The antibody does not cross-react with other Caspase family members.
Dilution WB~~1:5000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCaspase-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP7
Synonyms MCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
Research Areas
Citations (0)

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Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-7 (CMH-1, Mch3, ICE-LAP3) is an effector caspase involved in the activation cascade for apoptosis execution (1,2,3). Pro-Caspase-7 is a 35-kDa protein localized to the cytoplasm and expressed in a variety of tissues and cell lines (1). Upon activation, Caspase-7 is translocated to the mitochondria, and proceeds to proteolytically cleave poly(ADP-ribose) polymerase (PARP) (2,3) and endoplasmic reticular-specific substrate, sterol regulatory element-binding protein 1 (4).


1. Duan, H., et al. J. Biol. Chem. 271: 1621-5 (1996)
2. Lippke, J.A., et al. J. Biol. Chem. 271: 1825-8 (1996)
3. Fernandes-Alnemri, T., et al. Cancer Res. 55: 6045-52 (1995)
4. Chandler, J.M., et al. J. Biol. Chem. 273: 10815-10818 (1998)

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Cat# AJ1134a
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