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Caveolin-2 Antibody

Rabbit Monoclonal Antibody

  • WB - Caveolin-2 Antibody AJ1141a
    A.Western blot analysis on HeLa cell lysate using anti-Caveolin 2 RabMAb (Cat. #AJ1141a).
  • IHC - Caveolin-2 Antibody AJ1141a
    B.Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Caveolin 2 RabMAb. Note staining of endothelial cells and smooth muscles (Cat. #AJ1141a).
  • IF - Caveolin-2 Antibody AJ1141a
    C.Immunofluorescent staining of HeLa cells using anti-Caveolin 2 RabMAb (Cat. #AJ1141a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51636
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2220
Calculated MW 18291 Da
Gene ID 858
Other Names Caveolin-2, CAV2
Target/Specificity A synthetic peptide corresponding to residues surrounding Tyrosine 19 in human Caveolin 2 was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCaveolin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV2
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Cellular Location Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Tissue Location Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts
Research Areas
Citations (0)

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Caveolins are a family of caveolae-associated integral membrane proteins. Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking (1). Caveolin is a principal component of caveolae membranes. It interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects; however, they differ in their functional interactions with heterotrimeric G proteins, possibly explaining why Caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells, which is strictly dependent on continued treatment with NGF. Both Caveolin-1 and -2 are more abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Robust expression of Caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones (1).


1. Galbiati F, et al. Proc Natl Acad Sci USA 95(17):10257-62,1998
2. Scherer PE, et al. Proc Natl Acad Sci 93(1): 131-5, 1996

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Cat# AJ1141a
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