|Application ||WB, IF|
|Calculated MW||40844 Da|
|Other Names||C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CDw198, CCR8, CKRL1, CMKBR8, CMKBRL2|
|Target/Specificity||A synthetic peptide corresponding to residues in loop2 extracellular domain of human CKR8 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCR8/CKR8 Antibody (Loop 2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CKRL1, CMKBR8, CMKBRL2|
|Function||Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
CKR8/CCR8, or C-C chemokine receptor type 8, is a G protein-coupled, seven-transmembrane domain receptor protein. Chemokines are key molecules in directing leukocyte migration toward sites of inflammation. The human C-C chemokine I-309 is a monocyte chemoattractant and inhibits apoptosis in thymic cell lines. It has been found that CKR8/CCR8 is a receptor for chemokines SCYA1/I-309, SCYA4/MIP-1-beta, and SCYA17/TARC (1-3).
1. Tiffany, H.L., et al. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J. Exp Med. 186: 165
2. Goya, I., et al. Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 160: 19
3. Bernardini, G., et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol. 28: 582
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