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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CCT-alpha Antibody   

CCT-alpha Antibody

Rabbit Monoclonal IgG

  • WB - CCT-alpha Antibody AJ1147a
    Western blot analysis on (A) A549, (B) K562, (C) HeLa and (D) HepG2 cell lysates using anti-CCT-alpha RabMAb (Cat. #AJ1147a).
  • IF - CCT-alpha Antibody AJ1147a
    Immunofluorescent staining of HeLa cells using anti-CCT-alpha RabMAb (Cat. #AJ1147a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49585
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3941
Calculated MW 41731 Da
Gene ID 5130
Other Names Choline-phosphate cytidylyltransferase A, CCT-alpha, CTP:phosphocholine cytidylyltransferase A, CCT A, CT A, Phosphorylcholine transferase A, PCYT1A, CTPCT, PCYT1
Target/Specificity A synthetic peptide corresponding to residues in human CCT-alpha was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCT-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CTPCT, PCYT1
Function Controls phosphatidylcholine synthesis.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form.
Research Areas
Citations (0)

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CTP:phosphocholine cytidylyltransferase (CCT) is the key regulator enzyme in the synthesis of phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic cell membranes. CCT catalyzes the transfer of a cytidylyl group from CTP to phosphocholine to form CDP-choline (1). A steady, albeit low, production of PC is necessary to maintain suitable PC content for lipid homeostasis. However, elevated activity of CCT is required during cell division when increased PC production is needed for membrane biogenesis (2). To date, three CCT isoforms have been identified: CCT-alpha, CCT-beta 1, and CCT-beta 2 (3). CCT-alpha is localized to the nucleus and nuclear envelope in many cell types. An exception is lung-derived cell, where CCT-alpha is localized primarily in cytoplasmic and ER compartments. CCT-alpha is involved in important nuclear functions such as coordinating PC synthesis with cell-cycle regulation and regulating proliferation of the nucleoplasmic reticulum, an intranuclear membrane network implicated in calcium signaling and nuclear-cytoplasmic transport (4).


1. Lee, J., et al. J Biol Chem. 2009 2. Ridsdale et al. J. Biol. Chem. 276 (52) : 49148-49155, 2001. 3. Lykidis et al. J. Biol. Chem. 273 : 14022-14029. 4. Lagace, T., et al. Biochem. J. 392: 449-456, 2005

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Cat# AJ1147a
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