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CD72 Antibody

Rabbit Monoclonal Antibody

  • WB - CD72 Antibody AJ1168a
    Western blot analysis on K562 cell lysate using anti-CD72 RabMAb (Cat. #AJ1168a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21854
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3571
Calculated MW 40220 Da
Gene ID 971
Other Names B-cell differentiation antigen CD72, Lyb-2, CD72, CD72
Target/Specificity A synthetic peptide corresponding to residues in human CD72 was used as an immunogen.
Dilution WB~~1:2000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD72 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD72
Function Plays a role in B-cell proliferation and differentiation.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Pre-B-cells and B-cells but not terminally differentiated plasma cells
Research Areas
Citations (0)

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CD72, a type II integral membrane glycopotein and a member of the C-type lectin family of cell surface receptors, is expressed in all stages of B cell development except in terminally differentiated plasma cells (1). Ligation of CD72 enhances B cell growth and differentiation. CD72 transmits positive signals through association with Grb2 and or CD19 and negative signals through association with SHP-1 (2 and 3). CD72 has been reported to bind to CD5, suggesting a role in regulating T-cell activation and proliferation (4). Disregulated expression of CD72 was related to disease such as lupus nephritis (5) and primary Sj鰃ren?s syndrome (6).


1. Von Hoegen et al, J Immunol, 144 (12): 4870-4877, 1990 2. Wu et al, Immunol Res, 25(2):155-66, 2002 3. Wu et al, J Clin Immunol, 29(1):12-21, 2009 4. Luo et al, J Immunol, 148 :1630-1634, 1992 5. Nakano et al, Autoimmunity, 40(1) :9-15, 2007 6. Smith et al. Tissue Antigens, 63(3) :255-9, 2004

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Cat# AJ1168a
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