|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||25416 Da|
|Other Names||CD9 antigen, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein, MRP-1, Tetraspanin-29, Tspan-29, p24, CD9, CD9, MIC3, TSPAN29|
|Target/Specificity||A synthetic peptide corresponding to residues in human CD9 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CD9 belongs to the transmembrane 4 superfamily, also known as tetraspanin (TM4SF) family and is expressed in variety of hematopoietic and epithelial cells (1,2). It can form homodimers or homooligomers as well as heterooligomers with other members of the TM4SF family (3,4). It can trigger platelet activation and aggregation and modulate cell adhesion and migration. In addition, CD9 appears to promote muscle cell fusion and support. Downregualtion of CD9 has been reported to be associated with tumor progression and metastasis (5,6).
1. Lanza et al., J Biol Chem, 266;10638-10645, 1991 2. Rubinstein et al, Genomics, 16:132-138, 1993. 3. Rubinstein E et al., Eur J Immunol, 26(11):2657-65, 1996 4. Charrin et al., J Biol Chem, 276(17):14329-37, 2001 5. Wang et al. Clin Cancer Res. 13(8):2354-61, 2007. 6. De Bruyne et al. Clin Cancer Res, 14(10):2918-26, 2008.
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