|Application ||WB, IHC|
|Calculated MW||18848 Da|
|Other Names||CD99 antigen, E2 antigen, Protein MIC2, T-cell surface glycoprotein E2, CD99, CD99, MIC2, MIC2X, MIC2Y|
|Target/Specificity||A synthetic peptide corresponding to residues on the C-terminus of human CD99 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD99 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIC2, MIC2X, MIC2Y|
|Function||Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CD99, or protein MIC2, is a T-cell surface glycoprotein involved in the T-cell adhesion process and spontaneous rosette formation with erythrocytes. (1). The cell surface antigen defined by the monoclonal antibody CD99 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively (2). It was demonstrated that engagement of distinct epitopes on CD99 rapidly induces T cell death by a novel caspase-independent pathway. Thus, it is suggested that CD99 is linked to a novel death pathway that may have biologic relevance in control of early T cells (3).
1. Gelin C, et al. EMBO J. 8(11):3253-9, 1989
2. Goodfellow P, et al. Am J Hum Genet. 36(4):777-82, 1984
3. Pettersen RD, et al. J Immunol. 166(8):4931-42, 2001
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