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Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P02741 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | Y284 |
| Calculated MW | 25039 Da |
| Gene ID | 1401 |
| Other Names | C-reactive protein, C-reactive protein(1-205), CRP, PTX1 |
| Target/Specificity | A synthetic peptide corresponding to residues in the C-term of human c-Reactive protein was used as immunogen. This antibody is predicted to detect the splice isoform 2. |
| Dilution | WB~~1:1000 IHC~~1:100~250 |
| Format | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C-reactive Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRP |
|---|---|
| Synonyms | PTX1 |
| Function | Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
| Cellular Location | Secreted. |
| Tissue Location | Found in plasma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).
References
1. Tillet, W. S. & Francis, T. (1930) J. Exp. Med. 52,561-571
2. Kushner, I. (1982) Ann. N. Y. Acad. Sci. 389.39-48
3. Ridker, P. M.; Rifai, N.; Rose, L.; Buring, J. E.; Cook, N. R. : New Eng. J. Med. 347: 1557-1565, 2002.
4. Mortensen, R. F., Osmand, A. P., Lint, T. F. & Gewurz, H. (1976) J. Immunol. 117,774-781.
5. Kleemann R, Gervois PP, Verschuren L, Staels B, Princen HM, Kooistra T. Blood. 2003 Jan 15;101(2):545-51. Epub 2002 Aug 29.
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