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C-reactive Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - C-reactive Antibody (C-term) AJ1197a
    A. Western blot analysis on human serum using anti-c-Reactive protein RabMAb (Cat. #AJ1197a), 1:1,000 dilution.
  • IHC - C-reactive Antibody (C-term) AJ1197a
    B. Immunohistochemical analysis of paraffin-embedded human normal liver tissue using anti-c-Reactive protein RabMAb (Cat. #AJ1197a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02741
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y284
Calculated MW 25039 Da
Gene ID 1401
Other Names C-reactive protein, C-reactive protein(1-205), CRP, PTX1
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human c-Reactive protein was used as immunogen. This antibody is predicted to detect the splice isoform 2.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC-reactive Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRP
Synonyms PTX1
Function Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cellular Location Secreted.
Tissue Location Found in plasma.
Research Areas
Citations (0)

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Human c-Reactive protein (CRP) was discovered in serum of patients as a nonantibody precipitin of the C-polysaccharide from pneumococci(1). During acute infection, the amounts of circulating CPR increases 100-1000 fold (2). Serum CRP values are routinely measured to detect or monitor many human diseases and minor elevations of C-reactive protein are predictive of cardiovascular events in patients with coronary heart disease (3). CRP promotes host defense, is an efficient activator of the classical C cascade, and shown to be opsonic (4).The opsonic and C activation activities are responsible for the nonspecific host defense activities providing protection in the preimmune stage of acute infections. Additionally, IL-1 and IL-6 are known to stimulate CRP biosyntesis (5).


1. Tillet, W. S. & Francis, T. (1930) J. Exp. Med. 52,561-571
2. Kushner, I. (1982) Ann. N. Y. Acad. Sci. 389.39-48
3. Ridker, P. M.; Rifai, N.; Rose, L.; Buring, J. E.; Cook, N. R. : New Eng. J. Med. 347: 1557-1565, 2002.
4. Mortensen, R. F., Osmand, A. P., Lint, T. F. & Gewurz, H. (1976) J. Immunol. 117,774-781.
5. Kleemann R, Gervois PP, Verschuren L, Staels B, Princen HM, Kooistra T. Blood. 2003 Jan 15;101(2):545-51. Epub 2002 Aug 29.

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Cat# AJ1197a
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