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CrkL Antibody

Rabbit Monoclonal Antibody

  • WB - CrkL Antibody AJ1202a
    A. Western blot analysis on K562 cell lysate using anti-CrkL RabMAb (Cat. #AJ1202a), dilution 1:500
  • IHC - CrkL Antibody AJ1202a
    B. Immunohistochemical analysis of paraffin-embedded human metastatic lung carcinoma using anti-CrkL RabMAb (Cat. #AJ1202a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46109
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y244
Calculated MW 33777 Da
Gene ID 1399
Other Names Crk-like protein, CRKL
Target/Specificity A synthetic peptide corresponding to residues in the second SH3 domain and near C-terminus of human Crk-like protein was used as immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCrkL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May mediate the transduction of intracellular signals.
Research Areas
Citations (0)

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CrkL (Crk-like), a 36kDa protein predominantly expressed in hematopoietic cell lines, is a member of the Crk adapter protein family. Lacking any intrinsic enzymatic activity, CrkL is composed of one SH2 domain and two SH3 domains (1). The SH2 domain of CrkL as been shown to interact with c-Cbl, Cas, Hef-1 and Paxillin (2); while the N-terminal SH3 can bind to c-ABL, Sos1 and C3G (3). Additionally, the phosphorylated form of CrkL (pY207) binds to BCr-ABL oncogene in chronic myelogenous leukemia cells (4).


1. ten Hoeve J., Morris C., Heisterkamp N., Groffen J.; Oncogene 8:2469-2474(1993).
2. Kyono, W. T., de Jong, R., Park, R. K., Liu, Y., Heisterkamp, N., Groffen, J., and Durden, D. L. (1998) J. Immunol. 161, 5555-5563
3. Sattler, M., Salgia, R., Shrikhande, G., Verma, S., Uemura, N., Law, S. F., Golemis, E. A., and Griffin, J. D. (1997) J. Biol. Chem. 272, 14320-14326
4. Ling, P., Yao, Z., Meyer, C. F., Wang, X. S., Oehrl, W., Feller, S. M., and Tan, T. H. (1999) Mol. Cell. Biol. 19, 1359-1368

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Cat# AJ1202a
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