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CrkL Antibody Phospho (pY207)

Rabbit Monoclonal Antibody

  • WB - CrkL Antibody Phospho (pY207) AJ1203a
    A. Western blot analysis on K562 cell lysates using anti-Phospho-CrkL (pT207) RabMAb (Cat. #AJ1203a). Cells were either (A) untreated (B) treated with AP
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46109
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP270Y
Calculated MW 33777 Da
Gene ID 1399
Other Names Crk-like protein, CRKL
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human CrkL was used as immunogen. The antibody only detects CrkL phosphorylated on Tyrosine 207.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCrkL Antibody Phospho (pY207) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May mediate the transduction of intracellular signals.
Research Areas
Citations (0)

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CrkL (Crk-like), a 36kDa protein predominantly expressed in hematopoietic cell lines, is a member of the Crk adapter protein family. Lacking any intrinsic enzymatic activity, CrkL is composed of one SH2 domain and two SH3 domains (1). The SH2 domain of CrkL as been shown to interact with c-Cbl, Cas, Hef-1 and Paxillin (2); while the N-terminal SH3 can bind to c-ABL, Sos1 and C3G (3). Additionally, the phosphorylated form of CrkL (pY207) binds to BCr-ABL oncogene in chronic myelogenous leukemia cells (4).


1. Hoeve J, et al. Oncogene 8:2469-2474, 1993.
2. Kyono, W, et al. J. Immunol. 161:5555-5563, 1998.
3. Sattler, M, et al. J. Biol. Chem. 272:14320-14326, 1997.
4. Ling, P, et al. Mol. Cell. Biol. 19:1359-1368, 1999.

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Cat# AJ1203a
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