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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Cystatin B Antibody   

Cystatin B Antibody

Rabbit Monoclonal IgG

  • WB - Cystatin B Antibody AJ1215a
    Western blot analysis on (A) U87-MG, (B) JAR, and (C) human bladder cell lysates using anti-Cystatin B RabMAb (Cat. #AJ1215a).
  • IHC - Cystatin B Antibody AJ1215a
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Cystatin B RabMAb (Cat. #AJ1215a).
  • IHC - Cystatin B Antibody AJ1215a
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cystatin B RabMAb (Cat. #AJ1215a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04080
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3931
Calculated MW 11140 Da
Gene ID 1476
Other Names Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB
Target/Specificity A synthetic peptide corresponding to residues in human Cystatin B was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCystatin B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CST6, STFB
Function This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)

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Cystatin B is a member of the cysteine protease inhibitor superfamily, functioning as an intracellular thiol protease inhibitor (1). It plays a role in protecting proteinases from lysosomal leakage (1, 2). The second hairpin loop and the C-terminal end of Cystatin B anchor the inhibitor to target proteinases (3). Cystatin B interacts with and inhibits proteases of the cathepsin family (4). A deficiency in cystatin B is observed in progressive myoclonic epilepsy type 1 (1). This deficiency predisposes neurons to oxidative stress that leads to neuronal death and degeneration (1). In addition, Cystatin B has been linked to amyloid fibril formation in vitro and is overexpressed in hepatocellular carcinoma (5, 6).


1. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins U, Baltimore, MD. MIM Number: {601145}: {11/27/2006}: . WWW URL: 2. Lehtinen MK et al. J Neurosci. 29(18):5910-5, 2009. 3. Pol E et al. Biochemistry. 38(32):10519-26, 1999. 4. Riccio M et al. Exp Cell Res. 262(2):84-94, 2001. 5. Zerovnik E et al. Biochim Biophys Acta. 1594(1):1-5, 2002. 6. Lee MJ et al. Clin Cancer Res. 14(4):1080-9, 2008.

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Cat# AJ1215a
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