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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cytokeratin-10 Antibody   

Cytokeratin-10 Antibody

Rabbit Monoclonal Antibody

  •  - Cytokeratin-10 Antibody AJ1217a
    B. Paraffin-embedded human skin tissue stained with anti-CK-10 RabMAb. Note positive staining of suprabasal layers of keratinizing stratified epithelia (Cat. #AJ1217a).
  • WB - Cytokeratin-10 Antibody AJ1217a
    A. Western blot analysis on HaCat cell lysate using anti-cytokeratin 10 RabMAb (Cat. #AJ1217a), dilution 1:100,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13645
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1607Y
Calculated MW 58827 Da
Gene ID 3858
Other Names Keratin, type I cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KRT10, KPP
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Cytokeratin 10 was used as immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCytokeratin-10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT10
Synonyms KPP
Function Plays a role in the establishment of the epidermal barrier on plantar skin.
Cellular Location Secreted, extracellular space. Note=Localized on the surface of desquamated nasal epithelial cells.
Tissue Location Seen in all suprabasal cell layers including stratum corneum
Research Areas
Citations (0)

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Cytokeratin 10 (CK10) is a heterotetramer of two type I and two type II keratins. CK10 is typically associated with cytokeratin 1 (CK1). CK10 is expressed in all suprabasal cell layers, and it is part of the acidic/high molecular weight keratin subfamily. Defects in CK10 cause Epidermolytic hyperkeratosis (EHK), a hereditary skin hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum (1). CK10 has also been linked to cause annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. CK10, along with CK14, 15, 16, and 20, can be used to determine if a neoplasm originated from an epithelial or non-epithelial origin, such as the determination of metastatic malignant tumors of epithelial origin (2).


1. McGowan, K, et al; Journal of Investigative Dermatology 126:1013
2. Lin, Y, et al; Modern Pathology 17:1129

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Cat# AJ1217a
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