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Dsh-3 Antibody

Rabbit Monoclonal Antibody

  • WB - Dsh-3 Antibody AJ1246a
    A. Western blot analysis on K562 cell lysate using anti-Dsh-3 RabMAb (Cat. #AJ1246a), dilution 1:1000.
  • IHC - Dsh-3 Antibody AJ1246a
    B. Immunohistochemical staining of paraffin-embedded human brain tissue using anti-Dsh-3 RabMAb (Cat. #AJ1246a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92997
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1991Y
Calculated MW 78055 Da
Gene ID 1857
Other Names Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, DSH homolog 3, DVL3, KIAA0208
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human Dsh-3 was used as an immungen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDsh-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DVL3
Synonyms KIAA0208
Function Involved in the signal transduction pathway mediated by multiple Wnt genes.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O14641}.
Research Areas
Citations (0)

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The human DVL-3 gene encodes a predicted 716 amino acid protein which exhibits 98% amino acid identity with mouse Dsh-3 and 49% with Drosophila Dsh. Dsh-3 was mapped to 3q27. The expression of Dsh-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures. Dsh-3 mRNA was detected in normal human breast tissues and tumors. Statistically, there was no difference in Dsh-3 mRNA level between normal breast tissues and tumors. In human colorectal samples, Dsh-3 was expressed equally in matched normal tissues, polyps and tumors. The data indicates that Dsh-3 is widely expressed in human cells and may have a widespread role in signal transduction (1). Results indicate that the human dishevelled genes constitute a multigene family and that Dsh 3 proteins are highly conserved among metazoans.


1. Bui TD, et al. Biochem Biophys Res Commun 239(2): 510-6, 1997.
2. Semenov MV, et al. Genomics 42(2):302-10, 1997

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Cat# AJ1246a
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