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Filamin-A Antibody Phospho (pS2152)

Rabbit Monoclonal Antibody

  • WB - Filamin-A Antibody Phospho (pS2152) AJ1299c
    A. Western blot analysis on HeLa cell lysates using anti-Phospho-Filamin A (pS2152) RabMAb (Cat. #AJ1299c), 1:20,000 dilution. Cells were either (A) untreated (B) treated with calyculin A.
  • IHC - Filamin-A Antibody Phospho (pS2152) AJ1299c
    B. Immunohistochemical analysis of paraffin-embedded human uterus using anti-Filamin A RabMAb (Cat. #AJ1299c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21333
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP2310AY
Calculated MW 280739 Da
Gene ID 2316
Other Names Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1
Target/Specificity A phospho specific peptide corresponding to residues surrounding serine 2152 was used as an immunogen. This antibody detects filamin A phosphorylated on serine 2152.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFilamin-A Antibody Phospho (pS2152) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FLN, FLN1
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).
Cellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous actin in networks and stress fibers. Recently it has become clear that filamins anchor various transmembrane proteins to the actin cytoskeleton and provide a scaffold for a wide range of cytoplasmic signaling proteins (1). Actin-binding protein (Filamin A) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm, where it promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins (2). The actin-binding domain is near the amino-terminus of the subunit where the amino acid sequence is similar to other actin filament binding proteins, including alpha-actinin, beta-spectrin, dystrophin, and Dictyostelium abp-120. Detection of Filamin A /Fh1 proteins suggests that these presenilin-interacting proteins may be involved in the development of Alzheimer's disease and that interactions between presenilins and Filamin A /Fh1 may be functionally significant (3).


1. van der Flier A. Biochim Biophys 1538(2):99-117, 2001
2. Gorlin JB, et al. J Cell Biol 111(3):1089-105, 1990
3. Zhang W, et al. J Neurosci 18(3):914-22, 1998

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Cat# AJ1299c
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