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FKBP6 Antibody

Rabbit Monoclonal IgG

  • WB - FKBP6 Antibody AJ1301a
    Western blot analysis on (A) Molt-4 and (B) SAOS-2 cell lysates using anti-FKBP6 RabMAb (Cat. #AJ1301a).
  • IHC - FKBP6 Antibody AJ1301a
    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-FKBP6 RabMAb (Cat. #AJ1301a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75344
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3674
Calculated MW 37214 Da
Gene ID 8468
Other Names Inactive peptidyl-prolyl cis-trans isomerase FKBP6, Inactive PPIase FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FKBP-36, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36, FKBP6, FKBP36
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus in human FKBP6 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFKBP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP6
Synonyms FKBP36
Function Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Cellular Location Cytoplasm, cytosol. Nucleus. Chromosome. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).
Tissue Location Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney
Research Areas
Citations (0)

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FK506 binding protein 6 (FKBP6) is a cellular receptor for the immunosuppressants FK506 and rapamycin in the immunophilin FKBP family (1). FKBP's are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription (2). It forms a complex as FKBP-FK506 to competitively bind to and inhibit the Calcium- and calmodulin-dependent phosphatase calcineurin (3). FKBP6 plays a role in sex-specific fertility as a component of the synaptonemal complex, which is essential for chromosome pairing and meiotic division (4). A genetic deletion in FKBP6 is associated with Williams-Beuren syndrome (WBS), a neurodevelopmental disorder (5).


1. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: {604839}: {4/24/2006}: . World Wide Web URL: 2. Kang et al. Neurosignals. 16(4):318-25, 2008. 3. Liu et al. Cell. 66(4):807-15, 1991. 4. Crackower et al. Science. 300(5623):1291-5, 2003. 5. Metcalfe et al. Clin Dysmorphol. 14(2):61-5, 2005.

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Cat# AJ1301a
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