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GAP43 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - GAP43 Antibody (C-term) AJ1314c
    A. Western blot analysis on SH-SY5Y cell lysate using anti-GAP43 RabMAb (Cat. #AJ1314c).
  • IHC - GAP43 Antibody (C-term) AJ1314c
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-GAP43 RabMAb (Cat. #AJ1314c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17677
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP890Y
Calculated MW 24803 Da
Gene ID 2596
Other Names Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human GAP43 was used as an immunogen.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGAP43 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAP43
Function This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes
Research Areas
Citations (0)

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Growth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C (PKC), phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).


1. McIntosh H. et al. Visual Neuroscience.
2. Gianotti C, et al. Neuron 8:843-8, 1992.
3. Skene JH, et al. Science 233:783-786, 1986.
4. Neve RL, et al. J Neuro 18:7757-7767, 1998.

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Cat# AJ1314c
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