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GluR3 Antibody

Rabbit Monoclonal Antibody

  • WB - GluR3 Antibody AJ1324a
    A. Western blot analysis on human brain lysate using anti-GluR3 RabMAb (Cat. #AJ1324a), dilution 1:5,000
  • IHC - GluR3 Antibody AJ1324a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-GluR3 RabMAb (Cat. #AJ1324a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42263
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP813Y
Calculated MW 101157 Da
Gene ID 2892
Other Names Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3, GRIA3, GLUR3, GLURC
Target/Specificity A synthetic peptide corresponding to residues in the human Glutamate receptor type 3 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGluR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIA3
Synonyms GLUR3, GLURC
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.
Research Areas
Citations (0)

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Glutamate receptor type 3 (GluR3) is one of the four subunits of α-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). AMPA receptors are composed of four types of subunits, designated as GluR1, GluR2, GluR3, and GluR4 (alternatively called GluRA-D), which combine to form tetramers. The complex composed of GluR2 and GluR3 is one of the two predominant forms in the adult hippocampus. All four GluRs interact with specific cytoplasmic protein through their C-terminal tails. Although in contrast to GluR1 and GluR4, GluR3 and GluR2 have a short C-terminal tail.


1. Han, J.; Lee, J.-D.; Jiang, Y.; Li, Z.; Feng, L.; Ulevitch, R. J. : J. Biol. Chem. 271: 2886-2891, 1996.
2. Seger, R.; Krebs, E. G. : FASEB J. 9: 726-735, 1995.
3. Bernd Stein, Helen Brady, Maria X. Yang , David B. Young, Miguel S. Barbosa, Volume 271, Number 19, Issue of May 10, 1996 pp. 11427-11433
4. Fujishiro et al. J. Biol. Chem., Vol. 276, Issue 23, 19800-19806, 2001

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Cat# AJ1324a
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