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GRB2 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - GRB2 Antibody (C-term) AJ1331a
    A. Western blot analysis on 293 cell lysate using anti-GRB2 (C-term) RabMAb (Cat. #AJ1331a), dilution 1:10,000.
  • IHC - GRB2 Antibody (C-term) AJ1331a
    B. Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti- GRB2 (C-term) RabMAb (Cat. #AJ1331a).
  • IF - GRB2 Antibody (C-term) AJ1331a
    C. Immunofluorescent staining of HeLa cells using anti-GRB2 (C-term) RabMAb (Cat. #AJ1331a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62993
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y237
Calculated MW 25206 Da
Gene ID 2885
Other Names Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH
Target/Specificity A synthetic peptide corresponding to residues in the C-terminus of human GRB2 was used as an immunogen. This antibody can also detect the splice isoform GRB3-3 of GRB2.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRB2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRB2
Synonyms ASH
Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Cellular Location Nucleus. Cytoplasm. Endosome. Golgi apparatus
Research Areas
Citations (0)

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The growth factor bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain and two SH3 domains (1). GRB2 associates with Tyrosine phosphorylated EGFRs and PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin receptor to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adaptor protein, recruits Sos for Ras activation and subsequent signal transmission (3).


1. Matuoka, K.; Shibata, M.; Yamakawa, A.; Takenawa, T.: Proc. Nat. Acad. Sci. 89: 9015-9019, 1992
2. Lowenstein, E. J.; Daly, R. J.; Batzer, A. G.; Li, W.; Margolis, B.; Lammers, R.; Ullrich, A.; Skolnik, E. Y.; Bar-Sagi, D.; Schlessinger, J.: Cell 70: 431-442, 1992.
3. Nioche P.; et al, JMB, Volume 315, Number 5, February ( 2002), 1167-1177(11)

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Cat# AJ1331a
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