- CITATIONS: 1
|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||15258 Da|
|Other Names||Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain, HBA1|
|Target/Specificity||A synthetic peptide corresponding to residues in human Hemoglobin alpha chain was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Hemoglobin alpha Antibody chain is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxygen transport from the lung to the various peripheral tissues.|
|Tissue Location||Red blood cells.|
Provided below are standard protocols that you may find useful for product applications.
Hemoglobin alpha chain belongs to the globin family and is involved in oxygen transport from the lung to the various peripheral tissues. It is a heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2). Hemoglobin alpha chain is expressed in red blood cells and defects in HBA1/HBA2 can lead to alpha thalassemia, the most common of monogenic diseases (1).
1. The UniProt Consortium. The Universal Protein Resource (UniProt). 36: D190-D195 (2008).
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