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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Histone Deacetylase 2 Antibody (C-term)   

Histone Deacetylase 2 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Histone Deacetylase 2 Antibody (C-term) AJ1347a
    A. Western blot analysis on K562 cell lysate using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a), 1:2,000
  • IHC - Histone Deacetylase 2 Antibody (C-term) AJ1347a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a).
  • IF - Histone Deacetylase 2 Antibody (C-term) AJ1347a
    C. Immunofluorescent analysis of HeLa cells using anti-Histone Deacetylase 2 (C-term) RabMAb (Cat. #AJ1347a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92769
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y461
Calculated MW 55364 Da
Gene ID 3066
Other Names Histone deacetylase 2, HD2, HDAC2
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Histone Deacetylase 2 was used as immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHistone Deacetylase 2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC2
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed; lower levels in brain and lung
Research Areas
Citations (0)

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Histone deacetylase 2 (HDAC2) belongs to the histone deacetylase family type 1 which is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (1). HDAC2 represses transcription and binds transcription factor YY1 to form a large complex (2). It also forms transcriptional repressor complexes by associating with MAD, SIN3, N-CoR and DNMT1 (3-4). Similar to HDAC1 and HDAC3, HDAC2 does not possess a repression domain, but preferentially associates with HDAC1. HDAC2 with HDAC1 is also implicated in a complex of multiproteins that functions through modifying chromatin structure to keep genes silent (5).


1. Yang, W.-M.; Inouye, C.; Zeng, Y.; Bearss, D.; Seto, E.: Proc. Nat. Acad. Sci. 93: 12845-12850, 1996.
2. Inouye, C. J.; Seto, E.: J. Biol. Chem. 269: 6506-6510, 1994.
3. Tong, J. K., Hassig, C. A., Schnitzler, G. R., Kingston, R. E. & Schreiber, S. L. (1998) Nature (London) 395, 917-921
4. Rountree, M. R.; Bachman, K. E.; Baylin, S. B.: Nature Genet. 25: 269-277, 2000.
5. Hakimi et al. J. Biol. Chem. 278: 7234-7239, 2003

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Cat# AJ1347a
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