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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HNF4 Alpha Antibody   

HNF4 Alpha Antibody

Rabbit Monoclonal IgG

  • WB - HNF4 Alpha Antibody AJ1366b
    Western blot analysis on (A) HepG2, (B) A549 and (C) SW480 cell lysates using anti-HNF4 Alpha RabMAb (Cat. #AJ1366b).
  • IHC - HNF4 Alpha Antibody AJ1366b
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-HNF alpha RabMAb (Cat. #AJ1366b).
  • IHC - HNF4 Alpha Antibody AJ1366b
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-HNF alpha RabMAb (Cat. #AJ1366b).
  • IF - HNF4 Alpha Antibody AJ1366b
    Immunofluorescent staining of HepG2 cells using anti-HNF4 alpha RabMAb (Cat. #AJ1366b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41235
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3648
Calculated MW 52785 Da
Gene ID 3172
Other Names Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
Target/Specificity A synthetic peptide corresponding to residues in human HNF4 Alpha was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNF4 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF4A
Synonyms HNF4, NR2A1, TCF14
Function Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.
Cellular Location Nucleus.
Research Areas
Citations (0)

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HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein belonging to the steroid hormone receptor superfamily. HNF4 is commonly expressed in the liver and plays a critical role in liver development by establishing and maintaining hepatocyte differentiation (1). In human, two isoforms of HNF4 exists, alpha and gamma. HNF4 alpha is transcriptionally controlled transcription factor, which binds to DNA sites required for the transcription of alpha 1- antitrypsin, Apo CIII, transthyretin genes, and HNF1 alpha (2). HNF4 alpha interacts with PGC-1 to activate gluconeogenesis, leading to lipoprotein metabolism regulation (3). HNF4 alpha defects are known to cause type I diabetes (4).


1. Lazarevich NL, Al'pern DV. Mol Biol (Mosk). 42(5):786- 797, 2008. 2. Protein ID: P41235; The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res. 35:D193-D197, 2007. 3. Rhee, J. et al PNAS USA 100 :4012-4017, 2003. 4. Fajans SS et al., N Engl J Med 345 (13): 971?980, 2001.

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Cat# AJ1366b
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