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HSF4 Antibody (Isoform a)

Rabbit Monoclonal Antibody

  • WB - HSF4 Antibody (Isoform a) AJ1376a
    A. Western blot analysis on HeLa cell lysate using anti-HSF4a RabMAb (Cat. #AJ1376a), dilution 1:10,000.
  • IHC - HSF4 Antibody (Isoform a) AJ1376a
    B. Immunohistochemical analysis of paraffin-embedded human muscle using anti-HSF4a RabMAb (Cat. #AJ1376a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9ULV5
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1719Y
Calculated MW 53011 Da
Gene ID 3299
Other Names Heat shock factor protein 4, HSF 4, hHSF4, Heat shock transcription factor 4, HSTF 4, HSF4
Target/Specificity A synthetic peptide corresponding to residues in human HSF4 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSF4 Antibody (Isoform a) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSF4
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.
Cellular Location Nucleus.
Tissue Location Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues
Citations (0)

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Heat shock transcription factors (HSFs) mediate the inducible transcriptional response of genes that encode heat shock proteins and molecular chaperones. HSF4 a novel member of the HSF family that shares properties with other members of the HSF family yet appears to be functionally distinct. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. HSF4 represents a novel HSF that exhibits tissue-specific expression and functions to repress the expression of genes encoding heat shock proteins and molecular chaperones. HSF4 is preferentially expressed in the human heart, brain, skeletal muscle, and pancreas (1). The expression of heat shock genes is controlled at the level of transcription by members of the heat shock transcription factor family in vertebrates. HSF4 is characterized by its lack of a suppression domain that modulates formation of DNA-binding homotrimer (2)


1. Nakai A, et al. Mol Cell Biol 17(1):469-81, 1997
2. Tanabe M, et al. J Biol Chem 274(39):27845-56, 1999

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Cat# AJ1376a
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