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IFN gamma Antibody

Rabbit Monoclonal Antibody

  • WB - IFN gamma Antibody AJ1387a
    A. Western blot analysis on IFN-gamma recombinant protein (0.01ug/lane) using anti-IFN-gamma RabMAb (Cat. #AJ1387a), dilution 1:2,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01579
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1109Y
Calculated MW 19348 Da
Gene ID 3458
Other Names Interferon gamma, IFN-gamma, Immune interferon, IFNG
Target/Specificity A synthetic peptide corresponding to residues human IFN-γ was used as an immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFN gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Cellular Location Secreted.
Tissue Location Released primarily from activated T lymphocytes
Research Areas
Citations (0)

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Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN-γ), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN-γ is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN-γ expression is induced by IL-2, TNF-α and IL-12 and suppressed by IL-4, IL-10, and TGF-β (2). IFN-γ binds to IFN-γ receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-γ protects against tumor development and directs immunogenic phenotype (3). IFN-γ has been implicated various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4).


1. Bach EA et al. Annu. Rev. Immunol. 15;563-591, 1997.
2. Sen, GC et al. Viruses and interferons Annu. Rev. Microbiol. 55:255
3. Schroder K et al. Journal of Leukocyte Biology, 75:163-189, 2004.
4. Panitch HS et al. Lancet 1,893-895, 1987.

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Cat# AJ1387a
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