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IL-15 Antibody

Rabbit Monoclonal Antibody

  • WB - IL-15 Antibody AJ1393a
    A. Western blot analysis using anti-IL-15 RabMAb (Cat. #AJ1393a), dilution 1:5,000. (Approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40933
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP433Y
Calculated MW 18086 Da
Gene ID 3600
Other Names Interleukin-15, IL-15, IL15
Target/Specificity A recombinant human IL-15 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL15
Function Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Cellular Location Isoform IL15-S48AA: Secreted.
Tissue Location Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus
Research Areas
Citations (0)

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Interleukin 15 (IL-15) is a cytokine that shares many biological activities with IL-2. Both cytokines interact with the β and γ component of the IL-2 receptor. However, unlike IL-2 which is secreted only by T cells, IL-15 is expressed preferentially by nonlymphoid tissues, epithelial, and fibroblast cell lines (1). Two isoforms of human IL-15 are known. The longer form is localized to the plasma membrane or may be secreted, while the other (the shorter form) is found within the cytoplasm and the nucleus (2). IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells (3-4). It also induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes (5).


1. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D, EMBO J 13:2822, 1994
2. Gaggero, A., B. Azzoarone, C. Andrei, A. Mishal, R. Meazza, E. Zappia, A. Rubertelli, S. Ferrini. 1999. Eur. J. Immunol. 29:1265.
3. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH, J Immunol 154:483, 1995
4. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255, 1995
5. McInnes, I. B., J. Al-Mughales, M. Field, B. P. Leung, F. P. Huang, R. Dixon, R. D. Sturrock, P. C. Wilkinsin, F. Y. Liew. 1998. Nat. Med. 2:175.

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Cat# AJ1393a
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