|Application ||WB, IHC|
|Calculated MW||21099 Da|
|Other Names||Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa, IL18BP|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human IL18BP was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-18BP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.|
|Tissue Location||Strongly expressed in heart, lung, placenta and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).
1. Nicklin MJ, et al. Genomics 79, 718-725, 2002.
2. Nakanishi K, et al. Annu. Rev. Immunol. 19, 423-474, 2001
3. Aizawa Y, et al. FEBS Lett. 445(2-3):338-42, 1999.
4. Meng X, et al. Virology 358(1):211-20, 2007.
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