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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL-18BP Antibody   

IL-18BP Antibody

Rabbit Monoclonal Antibody

  • WB - IL-18BP Antibody AJ1395a
    A. Western blot analysis on HeLa cell lysate using anti-IL18BP RabMAb (Cat. #AJ1395a), dilution 1:500.
  • IHC - IL-18BP Antibody AJ1395a
    B. Immunohistochemical staining of paraffin-embedded human tonsils using anti-IL18BP RabMAb (Cat. #AJ1395a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95998
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1088Y
Calculated MW 21099 Da
Gene ID 10068
Other Names Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa, IL18BP
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human IL18BP was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-18BP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL18BP
Function Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
Cellular Location Secreted.
Tissue Location Strongly expressed in heart, lung, placenta and spleen.
Research Areas
Citations (0)

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IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).


1. Nicklin MJ, et al. Genomics 79, 718-725, 2002.
2. Nakanishi K, et al. Annu. Rev. Immunol. 19, 423-474, 2001
3. Aizawa Y, et al. FEBS Lett. 445(2-3):338-42, 1999.
4. Meng X, et al. Virology 358(1):211-20, 2007.

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Cat# AJ1395a
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