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IL-3R beta Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - IL-3R beta Antibody (C-term) AJ1398a
    A. Western blot analysis on TF-1 cell lysate using anti-IL3-R RabMAb (Cat. #AJ1398a), dilution 1:5000
  • IHC - IL-3R beta Antibody (C-term) AJ1398a
    B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-IL3-R RabMAb (Cat. #AJ1398a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32927
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1037Y
Calculated MW 97336 Da
Gene ID 1439
Other Names Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB
Target/Specificity A synthetic peptide corresponding to residues in the C-terminus of human IL-3R Beta was used as an immunogen.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL-3R beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IL3RB, IL5RB
Function High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).


1. Stomski FC, et al. Mol Cell Bio 16:3035-3046, 1996.
2. Hayashida K, et al. Proc Natl Acad Sci USA 87:9655, 1990
3. Dirksen U, et al. J Clin Invest 100:2211-2217, 1997.
4. Weiss M, et al. Blood 82:3298, 1993

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Cat# AJ1398a
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