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IRAK-3 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - IRAK-3 Antibody (C-term) AJ1411a
    A. Western blot analysis on A431 cell lysate using anti-IRAK-3 (C-term) RabMAb (Cat. #AJ1411a), dilution 1:20,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y616
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y278
Calculated MW 67767 Da
Gene ID 11213
Other Names Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH578001}
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRAK-3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRAK3 {ECO:0000312|EMBL:AAH57800.1}
Function Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue Location Expressed predominantly in peripheral blood lymphocytes.
Research Areas
Citations (0)

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IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).


1. Cao, Z., W. J. Henzel, X. Gao. 1996. Science271:11282.
2. Kanakaraj, P., K. Ngo, Y. Wu, A. Angulo, P. Ghazal, C. A. Harris, J. J. Siekierka, P. A. Peterson, W. P. Fung-Leung. 1999. J. Exp. Med.189:1129
3. H., Gao, X., Li, X., Kirschning, C.J., Stark, G.R. and Cao, Z., 1999. J. Biol. Chem. 274, pp. 19403
4. Muzio, M., Ni, J., Feng, P. and Dixit, V.M., 1997. Science 278, pp. 1612
5. Koichi Kobayashi, Lorraine D. Hernandez, Jorge E. Gal

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Cat# AJ1411a
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