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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Lipin-1 Antibody   

Lipin-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Lipin-1 Antibody AJ1446a
    Western blot analysis on (A) Jurkat, (B) HepG2 and (C) HuT-78 cell lysates using anti-Lipin-1 RabMAb (Cat. #AJ1446a).
  • IHC - Lipin-1 Antibody AJ1446a
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Lipin1 RabMAb (Cat. #AJ1446a).
  • IHC - Lipin-1 Antibody AJ1446a
    Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Lipin1 RabMAb (Cat. #AJ1446a).
  • IF - Lipin-1 Antibody AJ1446a
    Immunofluorescent staining of HepG2 cells using anti-Lipin1 RabMAb (Cat. #AJ1446a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14693
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3725
Calculated MW 98664 Da
Gene ID 23175
Other Names Phosphatidate phosphatase LPIN1, Lipin-1, LPIN1, KIAA0188
Target/Specificity A synthetic peptide corresponding to residues in human Lipin-1 was used as an immunogen.
Dilution WB~~1:20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLipin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPIN1
Synonyms KIAA0188
Function Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).
Cellular Location Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane
Tissue Location Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.
Research Areas
Citations (0)

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Lipin-1 is a Mg(2)+-dependent phosphatidate phosphatase (PAP) enzyme which catalyzes the conversion of phosphatidate to diacylglycerol, a key reaction in glycerolipid biosynthesis (1). It plays critical roles in controlling energy metabolism, has establishing the adipogenic gene expression program during early stages of differentiation, and in triglyceride accumulation in mature adipocytes (2, 3). Lipin-1 also functions as a transcriptional coactivator in conjunction with members of the peroxisome proliferator-activated receptor (PPAR) family (2). There are two isoforms of Lipin-1 (alpha and beta) which appear to serve distinct functions in adipocytes, with unique expression dynamics, subcellular localization, and effects on gene expression. Lipin-1B is the predominant form in mature adipocytes. Lipin-1 expression levels are associated with insulin sensitivity, metabolic rate, hypertension, and risk for the metabolic syndrome (4).


1. Peixiang Zhang, et al. Journal of Lipid Research 49: 1519-1528, 2008 2. Donkor J, et al. J Biol Chem. 2009 3. Croce MA, et al. Diabetes. 56(9):2395-9, 2007 4. Reue K., et al. FEBS Lett. 582(1):90-6, 2008

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Cat# AJ1446a
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