|Calculated MW||92272 Da|
|Other Names||Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 3422-, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT|
|Target/Specificity||A synthetic peptide corresponding to residues in the N-term of human MALT1 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MALT1 (MLT1) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10|
|Tissue Location||Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung|
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Provided below are standard protocols that you may find useful for product applications.
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).
1. Uren AG, O'Rourke K, Aravind LA, et al. Mol Cell. 2000;6: 961-967
2. Lucas PC, Yonezumi M, Inohara N, et al. J Biol Chem. 2001;276: 19012-19019.
3. Zhou H, Wertz I, O'Rourke K, et al. Nature. 2004;427: 167-171.
4. Dierlamm et al.; Blood 1999, 93:3601-3609
5. Akagi et al. Oncogene 1999, 18:5785-5794
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