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MAP2 Antibody Phospho (pS136)

Rabbit Monoclonal Antibody

  • WB - MAP2 Antibody Phospho (pS136) AJ1455a
    Western blot analysis on fetal brain lysates using anti-Phospho-MAP2 (pS136) RabMAb (Cat. #AJ1455a). Cells were either (A) untreated (B) treated with Alkaline Phosphatase. Fig 1C. Western blot analysis on mouse brain lysates using anti-Phospho-MAP2 (pS136) RabMAb (Cat. #AJ1455a).
  • IHC - MAP2 Antibody Phospho (pS136) AJ1455a
    Immunohistochemical analysis of paraffin-embedded human brain tissue using Phospho-specific anti-MAP2 RabMAb (Cat. #AJ1455a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11137
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR2361
Calculated MW 199526 Da
Gene ID 4133
Other Names Microtubule-associated protein 2, MAP-2, MAP2
Target/Specificity A phospho-specific peptide corresponding to residues surrounding Serine 136 of human MAP2 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP2 Antibody Phospho (pS136) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP2
Function The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, dendrite {ECO:0000250|UniProtKB:P20357}
Research Areas
Citations (0)

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Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP2a, and MAP2b (280 kDa), MAP2c (75 kDa)) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics (1). MAP2 is proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuronal cell death. MAP2 may perform many functions including the nucleation and stabilization of microtubules, the regulation of organelle transport within axons and dendrites, as well as the anchorage of regulatory proteins such as protein kinases which may be important for signal transduction (2). MAP2 is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity. Findings suggest that epinephrine induces phosphorylation of MAP2c at Serine 136 through an alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neuritis (3).


1. Shafit-Zagardo B, et al. Mol Neurobiol. 16(2):149-62, 1998 2. S醤chez C, et al. Prog Neurobiol. 61(2):133-68, 2000 3. Liu Y, et al. Adv Anat Pathol. 10(2):101-6, 2003

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Cat# AJ1455a
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