|Application ||WB, IHC|
|Calculated MW||60179 Da|
|Other Names||Macrophage colony-stimulating factor 1, CSF-1, M-CSF, MCSF, Lanimostim, Processed macrophage colony-stimulating factor 1, CSF1|
|Target/Specificity||A synthetic peptide corresponding to residues on human M-CSF was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||M-CSF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Colony stimulating factor-1 (M-CSF) is a glycoprotein growth factor required for the proliferation and differentiation of mononuclear phagocytic cells. Findings indicate that M-CSF, under hormonal influence, plays a role in placental development and function and that steroid hormones may regulate developmental processes via their effects on the expression of tissue-specific growth factors (1). M-CSF accelerates neointimal formation after vascular injury via the SDF-1-CXCR4 system, and the inhibition of this system has therapeutic potential for the treatment of cardiovascular diseases (2). The immunosuppressor Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability (3). Several studies have demonstrated that CSFs are closely associated with tumor progression, metastasis and invasion through autocrine or paracrine mechanism in lung cancer (4).
1. Pollard JW, et al. Nature 330(6147):484-6, 1987.
2. Shiba Y, et al. Arterioscler Throm Vasc Biol, 27(2):283- 9,006
3. Sanchez-Tillo E, et al. Eur J Immunol. 36(9):2515-24, 2006
4. Uemura Y, et al. Int J Mol Med 18(2):365-73, 2006.
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