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MEKK2 Antibody

Rabbit Monoclonal Antibody

  • WB - MEKK2 Antibody AJ1470a
    A. Western blot analysis on Jurkat cell lysate using anti-MEKK-2 RabMAb (Cat. #AJ1470a), dilution 1:50,000.
  • IHC - MEKK2 Antibody AJ1470a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-MEKK2 RabMAb (Cat. #AJ1470a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2U5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP626Y
Calculated MW 69741 Da
Gene ID 10746
Other Names Mitogen-activated protein kinase kinase kinase 2, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2, MAP3K2, MAPKKK2, MEKK2
Target/Specificity A synthetic peptide corresponding to residues near the N-term of human MEKK-2 was used as immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEKK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K2
Synonyms MAPKKK2, MEKK2
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Cellular Location Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus
Research Areas
Citations (0)

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MEKK2 is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP/ERK kinase kinase family (1). Closely related to MEKK3, MEKK2 is expressed in a multitude of tissues. MEKK2 directly phosphorylates and activates Ikappa B kinases and has been found to bind and activate protein kinase C-related kinase 2 (2). MEKK2 has also been known to activate JNK1/2, ERK1/2, p38, and ERK5 MAPK in vitro (3). MEKK2 interacting protein (Mip1) regulates MEKK2 expression (4).


1. Blank, J. L., P. Gerwins, E. M. Elliott, S. Sather, and G. L. Johnson. 1996.; J. Biol. Chem. 271:5361-5368.
2. Deacon, K., and J. L. Blank. 1997. J. Biol. Chem. 272:14489-14496
3. Cheng, J., J. Yang, Y. Xia, M. Karin, and B. Su. 2000. Mol. Cell. Biol. 20:2334-2342
4. Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, Bing Su; Mol. and Cell. Biol., July 2005, p. 5955-5964, Vol. 25, No. 14

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Cat# AJ1470a
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