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MEKK3 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - MEKK3 Antibody (C-term) AJ1470c
    A. Western blot analysis on Hela cell lysate using anti-MEKK3 (C-term) RabMAb (Cat. #AJ1470c), dilution 1:1,000.
  • IHC - MEKK3 Antibody (C-term) AJ1470c
    B. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma using anti-MEKK3 (C-term) RabMAb (Cat. #AJ1470c).
  • IF - MEKK3 Antibody (C-term) AJ1470c
    C. Immunofluorescent staining of HeLa cells using anti-MEKK3 (C-term) RabMAb (Cat. #AJ1470c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99759
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP600Y
Calculated MW 70898 Da
Gene ID 4215
Other Names Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human MEKK3 was used as immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEKK3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K3
Synonyms MAPKKK3, MEKK3
Function Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
Research Areas
Citations (0)

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MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).


1. Blank, J. L., P. Gerwins, E. M. Elliott, S. Sather, and G. L. Johnson. 1996.; J. Biol. Chem. 271:5361-5368.
2. Zhang et al.: J. Biol. Chem. 272: 2668-2674, 1997.
3. Zhao, Q., and Lee, F. S. (1999) J. Biol. Chem. 274, 8355
4. Wilson, M. I., Gill, D. J., Perisic, O., Quinn, M. T., and Williams, R. L. (2003) Mol. Cell 12, 39
5. P.L. Channavajhala, L. Wu, J.W. Cuozzo, J.P. Hall, W. Liu, L.L. Lin, Y. Zhang, J. Biol. Chem. 278 (2003) 47089-47097

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Cat# AJ1470c
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