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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MEKK4 Antibody   

MEKK4 Antibody

Rabbit Monoclonal Antibody

  • WB - MEKK4 Antibody AJ1471a
    A. Western blot analysis on 293 cell lysate using anti-MEKK4 RabMAb (Cat. #AJ1471a), dilution 1:1,000.
  • IHC - MEKK4 Antibody AJ1471a
    B. Immunohistochemical analysis of paraffin-embedded human ovary adenocarcinoma using anti-MEKK4 RabMAb (Cat. #AJ1471a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6R4
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP551Y
Calculated MW 181685 Da
Gene ID 4216
Other Names Mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Target/Specificity A synthetic peptide corresponding to residues in human MEKK4 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEKK4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K4
Synonyms KIAA0213, MAPKKK4, MEKK4, MTK1
Function Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Cellular Location Cytoplasm, perinuclear region. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.
Tissue Location Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
Research Areas
Citations (0)

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MEK kinase 4 (MEKK4), also known as MTK1, is a Ser/Thr protein kinase belonging to the MAP kinase kinase kinase family (1). This protein contains a protein kinase catalytic domain at the C-terminus. The N-terminal, non-kinase domain may contain a regulatory domain. MEKK4 regulates p38 and JNK, butnot ERK pathway, through the phosphorylation of the MAP2Ks MKK3 and MKK6 and MKK4 and MKK7 respectively (1-2).


1. Takekawa, M.F. Posas, and H. Saito. 1997 EMBO J. 16:4973-4982
2. Gerwins, P., J.L. Blank, and G.L. Johnson. 1997. J. Biol. Chem. 272:8288-8295

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Cat# AJ1471a
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