Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Menin Antibody   

Menin Antibody

Rabbit Monoclonal IgG

  • WB - Menin Antibody AJ1473a
    Western blot analysis on (A) Jurkat, (B) 293T, (C) K562, (D) A431 and (E) HeLa cell lysates using anti-Menin RabMAb (Cat. #AJ1473a).
  • IHC - Menin Antibody AJ1473a
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Menin RabMAb (Cat. #AJ1473a).
  • IHC - Menin Antibody AJ1473a
    Immunohistochemical analysis of paraffin-embedded human papillary carcinoma of thyroid gland using anti-Menin RabMAb (Cat. #AJ1473a).
  • IF - Menin Antibody AJ1473a
    Immunofluorescent staining of HeLa cells using anti-Menin RabMAb (cat. #2817).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00255
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3986
Calculated MW 68023 Da
Gene ID 4221
Other Names Menin, MEN1, SCG2
Target/Specificity A synthetic peptide corresponding to residues at the C terminus of human Menin was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMenin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEN1
Synonyms SCG2
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Cellular Location Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Tissue Location Ubiquitous.
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Menin is a nuclear protein that is ubiquitously expressed (1). Inactivating germ line mutations of this gene causes multiple endocrine neoplasia type 1 (MEN1), an inherited syndrome characterized by the combined occurrence of parathyroid adenomas, gastroenteropancreatic tumors, pituitary tumors and several other tumor types (2). Menin interacts with nuclear proteins such as transcription factors, histone methyltransferases (HMT) and histone deacetylases (HDAC) to facilitate regulation of gene transcription and cellular homeostasis. Menin interacts with a number of transcriptional factors such as JunD, NF-kB, Smad3, and homeobox-containing DNA binding protein Pem and inhibits the activities of JunD and NF-kB (3,4,5). The Menin HMT complex was found to activate several target genes, including homeobox domain (Hox) genes, cyclin-dependent kinase inhibitors tumor suppressor genes and nuclear hormone receptor responsive genes (6). Menin was demonstrated to attenuate transcription of the telomerase (hTERT) gene, possibly depending on recruitment of deacetylation activity (7).


1. Guru et al. Proc Natl Acad Sci USA 95 : 1630-4, 1998. 2. Brandi et al. J clin Endocrinol Metab 86 : 5658-71, 2001. 3. Poisson et al. Cancer letters. 189 :1-10, 2003. 4. Agarwal et al. Cell 96 : 143-152, 1999. 5. Heppner et al. Oncogene 20 : 4917-25, 2001. 6. Yang et al. Mol Cell Endocrinol 265-266 : 34-41, 2007. 7. Hashimoto et al. Int J Oncol 33 : 333-40, 2008.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# AJ1473a
Alternative Products:

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions