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MIP-1 alpha Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - MIP-1 alpha Antibody (C-term) AJ1480a
    A. Western blot of anti-MIP1 alpha (C-term) RabMAb (Cat. #AJ1480a), dilution 1:50,000 (approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10147
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP493Y
Calculated MW 10085 Da
Gene ID 6348
Other Names C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, PAT 4641, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, MIP-1-alpha(4-69), LD78-alpha(4-69), CCL3, G0S19-1, MIP1A, SCYA3
Target/Specificity A synthetic peptide corresponding to residues in the C-terminus of human MIP 1 alpha was used as an immunogen.
Dilution WB~~1:50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMIP-1 alpha Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL3
Synonyms G0S19-1, MIP1A, SCYA3
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Cellular Location Secreted.
Research Areas
Citations (0)

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Macrophage inflammatory protein-1 alpha (MIP-1 alpha) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 alpha is involved in the acute inflammatory state, in the recruitment and activation of polymorphonuclear leukocytes and can inhibit infection of cells with human immunodeficiency virus type 1 (HIV-1) (2). MIP-1 alpha also acts as a potent growth, survival, and chemotactic factor in multiple melanoma cells. Two know isoforms of MIP-1 alpha can be found; LD78 alpha and LD78 beta (3). Depending on the isoform or its N-terminal processing, one or more of the CC chemokine receptors CCR1, CCR2, CCR3 and CCR5 can recognize MIP alpha, thus inhibiting HIV infection (4).


1. Jenne, D.; Stanley, K. K. EMBO J. 4: 3153-3157, 1985.
2. S.D. Wolpe, et al., J. Exp. Med. 167 (1988), pp. 570
3. D.R. Forsdycke Biochem. Biophys. Res. Commun. 28 (1985), pp. 619
4. Patricia Menten, Anja Wuyts and Jo Van Damme. Cytokine & Growth Factor Reviews 13,(2002) 455-481

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Cat# AJ1480a
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