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MMP-20 Antibody

Rabbit Monoclonal Antibody

  • WB - MMP-20 Antibody AJ1498a
    A. Western blot analysis on HeLa cell lysate using anti-MMP-20 RabMAb (Cat. #AJ1498a), dilution 1:500.
  • IF - MMP-20 Antibody AJ1498a
    B. Immunofluorescent staining of HeLa cells using anti-MMP-20 RabMAb (Cat. #AJ1498a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60882
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1275Y
Calculated MW 54387 Da
Gene ID 9313
Other Names Matrix metalloproteinase-20, MMP-20, 3424-, Enamel metalloproteinase, Enamelysin, MMP20
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human MMP-20 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP-20 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP20
Function Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed specifically in the enamel organ.
Research Areas
Citations (0)

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MMP-20 (enamelysin) is a recently discovered member of the MMP family. This enzyme is involved in the degradation of the various components of the extracellular matrix (ECM) during development, haemostasis and pathological conditions. MMP-20 expression has been found to be restricted to the enamel organ and due to its unique expression pattern, may primarily be involved in the turnover of these molecules during tooth development. The enamel matrix proteins amelogenin, ameloblastin, and enamelin are expressed during the developmental time period, suggesting that MMP-20 may play a role in their hydrolysis (1). Recombinant human enamelysin is able to degrade amelogenin, the major protein component of the enamel matrix. On the basis of its degrading activity on amelogenin, and its highly restricted expression to dental tissues, we suggest that human enamelysin plays a central role in the process of tooth enamel formation (2). Enamelysin null mice do not process amelogenin properly, possesses an altered enamel matrix and rod pattern, has hypoplastic enamel that delaminates from the dentin, and has a deteriorating enamel organ morphology as development progresses (3).


1. Stracke JO, et al. FEBS Lett 478(1-2):52-6, 2000.
2. Llano E, et al. Biochemistry 36(49):15101-8, 1997
3. Caterina JJ, et al. J BIol Chem 277(51):49598-604, 2002

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Cat# AJ1498a
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