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Mst4 Antibody

Rabbit Monoclonal Antibody

  • WB - Mst4 Antibody AJ1515a
    A. Western blot analysis on HeLa cell lysate using anti-Mst4 RabMAb (Cat. #AJ1515a).
  • IHC - Mst4 Antibody AJ1515a
    B. Immunohistochemical analysis of paraffin-embedded human placenta using anti-Mst4 RabMAb (Cat. #AJ1515a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P289
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1864Y
Calculated MW 46529 Da
Gene ID 51765
Other Names Serine/threonine-protein kinase 26, MST3 and SOK1-related kinase, Mammalian STE20-like protein kinase 4, MST-4, STE20-like kinase MST4, Serine/threonine-protein kinase MASK, STK26 (HGNC:18174)
Target/Specificity A synthetic peptide corresponding to residues on the N-terminus of human Mst4 was used as an immunogen.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMst4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK26 (HGNC:18174)
Function Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).
Cellular Location Cytoplasm. Golgi apparatus Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006)
Research Areas
Citations (0)

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Novel human Ste20-related kinase Mst4 is highly expressed in placenta, thymus, and peripheral blood leukocytes. Mst4 is biologically active in the activation of MEK/ERK pathway and in mediating cell growth and transformation (1). Wild type and C-terminally truncated forms of Mst4 can both induce apoptosis upon overexpression in mammalian cells that is abrogated by CrmA, suggesting involvement of Mst4 in the apoptotic machinery in mammalian cells (2). Mst4 was found to be expressed in prostate carcinoma tumor samples and cell lines. In addition, expression levels appeared to correlate with tumorigenicity and androgen receptor status of the cells. Mst4 kinase activity was stimulated significantly by epidermal growth factor receptor ligands, which are known to promote growth of prostate cancer cells (3).


1. Lin JL, et al. Oncogene 20(45):6559-69, 2001
2. Dan I, et al. J Biol Chem 277(8):5929-39, 2002
3. Sung V, et al. Cancer Res 63(12):3356-63, 2003

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Cat# AJ1515a
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