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Nur77 Antibody

Rabbit Monoclonal Antibody

  • WB - Nur77 Antibody AJ1556a
    Western blot analysis on (A) SH-SY5Y and (B) HepG2 on cell lysates using anti-Nur77 RabMAb (Cat. #AJ1556a).
  • FC - Nur77 Antibody AJ1556a
    Flow cytometric analysis of permeabilized HepG2 cells using anti- Nur77 RabMAb (red) (Cat. #AJ1556a) or a rabbit IgG (negative) (green).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22736
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3209
Calculated MW 64463 Da
Gene ID 3164
Other Names Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Nur77 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNur77 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR4A1
Synonyms GFRP1, HMR, NAK1
Function Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Fetal muscle and adult liver, brain and thyroid
Research Areas
Citations (0)

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Nur77 (TR3, NGFI-B) is an orphan nuclear receptor belonging to the steroid/thyroid hormone receptor superfamily with multiple cell functions relating to apoptosis, cell differentiation, and proliferation. Nur77 expression is rapidly induced by several growth factors, mitogens, and stress factors (1). With its central DNA binding domain, Nur77 binds to specific DNA elements and regulates the transcription of the target gene (2). While Nur77 activities are shown to be specific to its sub-cellular location, the phospholyation on Nur77 by various kinases (e.g. RSK, MSK) might affect its transactivation activity and its localization (3, 4). Nur77 localized in the nucleus functions as an oncogenic survival factor and promotes cell growth. However, in mitochondria, it functions as an apoptosis factor after binding to Bcl-2 and triggering cytochrome c release. Nur77 has been linked to apoptosis of immature T cell and T cell hybridoma. In tumors, it is involved in both apoptosis and proliferation of cancer cells (4).


1. Kolluri SK, Mol Cell Biol. 23(23):8651-67, 2003. 2. Wilson TE et al., Science 252:1296-1300, 1993. 3. Wingate WD et al., Biochem J. 393(Pt 3): 715?724, 2006 4 Zhang XK. Expert Opin Ther Targets. 11(1):69-79, 2007.

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Cat# AJ1556a
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