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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   p190-B RhoGAP Antibody   

p190-B RhoGAP Antibody

Rabbit Monoclonal Antibody

  • WB - p190-B RhoGAP Antibody AJ1567a
    A. Western blot analysis of anti-p190-B RhoGAP RabMAb (Cat. #AJ1567a) 1:500 dilution A-Hela B-Jurkat C-MCF-7 D-K562 E-A431 F-293 G-NIH 3T3 H-PC12
  • IHC - p190-B RhoGAP Antibody AJ1567a
    B. Immunohistochemical analysis of paraffin-embedded human stomach carcinoma using anti-p190-B RhoGAP RabMAb (Cat. #AJ1567a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13017
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP489Y
Calculated MW 172460 Da
Gene ID 394
Other Names Rho GTPase-activating protein 5, Rho-type GTPase-activating protein 5, p190-B, ARHGAP5, RHOGAP5
Target/Specificity A synthetic peptide corresponding to residues in human p190-B RhoGAP was used as immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsp190-B RhoGAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RHOGAP5
Function GTPase-activating protein for Rho family members (PubMed:8537347).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin
Tissue Location Detected in skin fibroblasts (at protein level) (PubMed:8537347).
Research Areas
Citations (0)

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The p190 Rho GTPase activating protein RhoGAP) family includes two closely related proteins, p190-A and p190-B. p190-B contains an N-terminal GTPase domain and a C-terminal Rho-GAP domain (1). p190-B can be directly phosphorylated on a single identified tyrosine residue by the activated insulin and IGF-1 receptors. This phosphorylation causes p190-B to translocate to the lipid rafts of the plasma membrane, where it can facilitate the inactivation of the Rho GTPase. P190-B also has been shown to be tyrosine phosphorylated by c-Src and v-Src. Additionall; the GAP domain of p190-B as shown to attenuate signal-transducing activity of Rac, Rho and CDC42 (2-3).


1. Burbelo et al. J. Biol. Chem. 270: 30919-30926, 1995.
2. Peter et al. Volume 270, Number 52, Issue of December 29, 1995 pp. 30919-30926
3. DZ Wang, MS Nur-E-Kamal, A Tikoo, W Montague and H Maruta. Cancer Research, Vol 57, Issue 12 2478-2484.

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Cat# AJ1567a

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