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PLAP Antibody

Rabbit Monoclonal Antibody

  • WB - PLAP Antibody AJ1628a
    A. Western blot analysis of anti-PLAP RabMAb (Cat. #AJ1628a), 1:1,000 dilution. A-MCF-7 B-K562
  • IHC - PLAP Antibody AJ1628a
    B. Immunohistochemical analysis of paraffin-embedded human lung metastatic cancer using anti-PLAP RabMAb (Cat. #AJ1628a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y263
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y102
Calculated MW 87157 Da
Gene ID 9373
Other Names Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP
Target/Specificity A synthetic peptide corresponding to residues near the N-term of human PLAP was used as immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PLAP
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
Cellular Location Nucleus. Cytoplasm. Cell junction, synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains
Research Areas
Citations (0)

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Phospholipase A2 activator protein (PLAP), activates PLA2 (phospholipase A2 enzyme) and is an important mediator of eicosanoid generation. Also known as a pro-inflammatory agent, PLAP has been found in inflamed tissues and synovial fluid from patients with rheumatoid arthritis. As such, it is believed to play an important role in the regulation of inflammatory diseases. The formation of PLAP can be stimulated by IL-1 beta and TNF-alpha (1-2).


1. Clark, M. A., T. M. Conway, R. G. L. Shorr, and S. T. Crooke. 1987. J. Biol. Chem. 262:4402
2. Chopra, A. K.; Ribardo, D. A.; Wood, T. G.; Prusak, D. J.; Xu, X.-J.; Peterson, J. W. : Biochim. Biophys. Acta 1444: 125-130, 1999.

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Cat# AJ1628a
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