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PLC-III Antibody Phospho (pS537)

Rabbit Monoclonal Antibody

  • WB - PLC-III Antibody Phospho (pS537) AJ1633a
    A. Western blot analysis on HeLa cell lysates using anti-Phospho-PLCB3 (pS537) RabMAb (Cat. #AJ1633a), 1:2000 dilution. Cells were either (A) untreated or (B) treated with TPA.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01970
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1498Y
Calculated MW 138799 Da
Gene ID 5331
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3
Target/Specificity A phosphor-specific peptide corresponding to residues surrounding Serine 537 of human PLC-β3 was used as an immunogen. This antibody detects PLC- β3 phosphorylated on Ser537.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLC-III Antibody Phospho (pS537) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCB3
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Cellular Location Membrane; Peripheral membrane protein.
Research Areas
Citations (0)

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PLC beta 3 plays an important role in initiating receptor-mediated signal transduction. Activation of PLC takes place in many cells as a response to stimulation by hormones, growth factors, neurotransmitters, and other ligands (1). PLCB3 plays an important role in signal transduction and, moreover, shows loss of expression in some endocrine tumors, in accordance with a putative tumor suppressor gene function (2). Morphine and other micro opioids regulate a number of intracellular signaling pathways, including the one mediated by phospholipase C (PLC). Data demonstrate that PLC beta3 constitutes a significant pathway involved in negative modulation of mu opioid responses, perhaps via protein kinase C, and suggests the possibility that differences in opioid sensitivity among individuals could be, in part, because of genetic factors (3).


1. Lagercrantz J, et al. Genomics 26(3):467-72, 1995.
2. Weber G, et al. Hum Genet 99(1):130-2, 1997.
3. Xie W, et al. Proc Natl Acad Sci, 96(18): 10385-90, 1999.

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Cat# AJ1633a
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