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PSD95 Antibody Phospho (pS295)

Rabbit Monoclonal Antibody

  • WB - PSD95 Antibody Phospho (pS295) AJ1661b
    A. Western blot analysis on (A, B) human brain tissue lysate and rat brain lysate (C, D) using anti-phospho PSD95 (pS295) RabMAb (Cat. #AJ1661b), 1:20,000 dilution. Cells were either (A, C) treated (B, D) untreated with LP
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78352
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP2615Y
Calculated MW 80495 Da
Gene ID 1742
Other Names Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, DLG4, PSD95
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding serine 295 of human PSD95 was used as immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPSD95 Antibody Phospho (pS295) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLG4
Synonyms PSD95
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:P31016}. Cell junction, synapse. Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. {ECO:0000250|UniProtKB:P31016}
Tissue Location Brain.
Research Areas
Citations (0)

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Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. Specifically, PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, and learning (2). Phospholyation of serine 295 on PSD95 is associated with its synaptic accumulation and synaptic function (3)


1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.
2. Cline, H. Curr. Biol. 15, R203-5, 2005.
3. Kim MJ, et al. Neuron 56: 488-502, 2007.

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Cat# AJ1661b
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