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RanGAP1 Antibody

Rabbit Monoclonal Antibody

  • WB - RanGAP1 Antibody AJ1676a
    Western blot analysis on (A) HeLa, (B) MCF-7, (C) SH-SY5Y and (D) A549 cell lysates using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IHC - RanGAP1 Antibody AJ1676a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IHC - RanGAP1 Antibody AJ1676a
    Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
  • IF - RanGAP1 Antibody AJ1676a
    Immunofluorescent staining of HeLa cells using anti-RanGAP1 RabMAb (Cat. #AJ1676a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46060
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3295
Calculated MW 63542 Da
Gene ID 5905
Other Names Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity A synthetic peptide corresponding to residues in human RanGAP1 was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRanGAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1835, SD
Function GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
Cellular Location Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305)
Tissue Location Highly expressed in brain, thymus and testis.
Research Areas
Citations (0)

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RanGAP1 is the activator of the Ras-related nuclear GTPase Ran, which is involved in the nucleo-cytoplasmic transport, mitotic spindle assembly, cell cycle control and nuclear envelope (NE) formation (1, 2). Its roles are accomplished by the asymmetric distribution of its GTP- and GDP-bound forms, enabled by the specific localization of Ran accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC. Mammalian RanGAP1 is targeted to the NE during interphase and to the spindle and kinetochores during mitosis via SUMOylated C-terminal domain and interaction with the nucleoporin Nup358/RanBP2 (2). RanGAP1 is highly expressed in brain, thymus and testis (3).


1. Krebber H., et al. Gene 180:7-11, 1996 2. Meier I, et al. J Microsc. 231(2):225-33, 2008 3. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195(2008)

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Cat# AJ1676a
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