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Rap1GAP Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - Rap1GAP Antibody (N-term) AJ1678b
    A. Western blot analysis on Jurkat cell lysate using anti-Rap1GAP (N-term) RabMAb (Cat. #AJ1678b), dilution 1:50,000.
  • IHC - Rap1GAP Antibody (N-term) AJ1678b
    B. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Rap1GAP (N-term) RabMAb (Cat. #AJ1678b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P47736
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y134
Calculated MW 73361 Da
Gene ID 5909
Other Names Rap1 GTPase-activating protein 1, Rap1GAP, Rap1GAP1, RAP1GAP, KIAA0474, RAP1GA1
Target/Specificity A synthetic peptide corresponding to residues following the GoLoco motif of human Rap1GAP was used as immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRap1GAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0474, RAP1GA1
Function GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Cellular Location Golgi apparatus membrane; Peripheral membrane protein
Tissue Location Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
Research Areas
Citations (0)

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Rap1GAP, an 85/95kDa protein, is a member of a family of GAPs specific for Rap1 (1). Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain (2-4). Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis (5).


1. Rubinfeld, B. et al. Cell 65, 1033−1042 (1991)
2. Polakis, P. G., Rubinfeld, B., Evans, T., and McCormick, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 239-243
3. Nice, E. C., Fabri, L., Hammacher, A., Holden, J., Simpson, R. J., and Burgess, A. W. (1992) J. Biol. Chem. 267, 1546-1553
4. Daumke, O. et al. Nature, Vol. 429, May 2004, 197-201
5. Manning, B.D. et al. Trends. Biochem. Sci. 28, 573-576 (2003)

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Cat# AJ1678b
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