Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Rheb Antibody   

Rheb Antibody

Rabbit Monoclonal Antibody

  • WB - Rheb Antibody AJ1687a
    A. Western blot analysis on (A) Raji and (B) SH-SY5Y cell lysates using anti-Rheb RabMAb (Cat. #AJ1687a), dilution 1:2000.
  • IHC - Rheb Antibody AJ1687a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Rheb RabMAb (Cat. #AJ1687a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15382
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2971
Calculated MW 20497 Da
Gene ID 6009
Other Names GTP-binding protein Rheb, Ras homolog enriched in brain, RHEB, RHEB2
Target/Specificity A synthetic peptide corresponding to residues in human Rheb was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRheb Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RHEB2
Function Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Cellular Location Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side
Tissue Location Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Rheb (Ras Homolog Enriched in brain) is a Ras-like small guanosine triphosphatase (GTPase) that is involved in cell growth and cell cycle progression. Rheb has also been suggested to have involvement in the TOR/S6K signaling pathway (1). It regulates the activity of the mammalian target of rapamycin, mTOR, a central regulator of cell growth, in response to growth factor stimulation and nutrient availability (2). It also interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, and is suggested to function in concert with H-Ras to dynamically integrate cAMP and growth factor signaling (3).


1. Tabancay AP Jr, et al. J Biol Chem. 278(41):39921-30, 2003
2. Hsu YC, et al. Nature. 445(7129):785-8, 2007
3. Bai X, et al. Science. 318(5852):977-80, 2007
4. WM Yee, et al. Mol. Cell. Biol. 17(2):921-933, 1997

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# AJ1687a
Alternative Products:

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions