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RIAM Antibody

Rabbit Monoclonal Antibody

  • WB - RIAM Antibody AJ1689b
    Western blot analysis on (A) Human Lymph node (B) Fetal brain (C) human spleen (D) Jurkat and (E) HL-60 + retinoic acid cell lysates using anti-RIAM RabMAb (Cat. #AJ1689b).
  • IHC - RIAM Antibody AJ1689b
    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-RIAM RabMAb (Cat. #AJ1689b-1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z5R6
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EPR2806
Calculated MW 73183 Da
Gene ID 54518
Other Names Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 73, Rap1-GTP-interacting adapter molecule, RIAM, Retinoic acid-responsive proline-rich protein 1, RARP-1, APBB1IP, PREL1, RARP1, RIAM
Target/Specificity A synthetic peptide corresponding to residues in human RIAM was used as an immunogen.
Dilution WB~~1:25000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRIAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PREL1, RARP1, RIAM
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion.
Cellular Location Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
Tissue Location Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes
Citations (0)

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RIAM (a Rap1-GTP-interacting adapter molecule) defines a family of adaptor molecules that contain a RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and various proline-rich motifs (1). RIAM directly binds to Ena/VASP proteins, important modulators of cell migration that localize to focal adhesions and stress fibers, and co-localizes with them at focal adhesions in response to Ras activation. Moreover, RIAM directly binds to activated Ras in a phosphoinositide-dependent manner. RIAM is believed to be the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading (2).


1. Lafuente EM, et al. Dev Cell 7(4):585-95, 2004 2. Jenzora A et al. FEBS Lett 579(2):455-63, 2005

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Cat# AJ1689b
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